It has been used safely in doses of up to 1.5 grams per day for 6 months. Common side effects include diarrhea, constipation, gas, and stomach upset. Although berberine appears to be generally safe at normal doses, more long-term research is needed on its safety. In some people, berberine supplementation has been reported to cause gastrointestinal side effects, such as diarrhea, constipation, flatulence, and stomach pain.
Because of its ability to lower blood sugar, berberine may increase the risk of hypoglycemia at high doses. Berberine has a high potential to interact with several medications, and some of these interactions increase the likelihood of serious complications. In summary, berberine is a potent oral hypoglycemic agent with a modest effect on lipid metabolism. It's safe and the cost of berberine treatment is very low.
May serve as a new drug candidate in the treatment of type 2 diabetes. However, this is a pilot study. The effectiveness of berberine should be tested in a much larger population and characterized according to the known duration of diabetes. More studies are needed to evaluate the action of berberine in type 2 diabetes in other ethnic groups.
Berberine is not intended for long-term use. There are no data available on the safety of berberine among young people who were assigned a woman at birth or early in pregnancy. And no one should take berberine while pregnant, nursing, or breastfeeding. The National Center for Complementary and Integrative Health (NCCIH) notes that if adults take the gold seal, which contains berberine, by mouth, it is unlikely to cause serious short-term adverse effects.
Although most uses of berberine have not yet been proven, some research has found evidence to support its use in people with PCOS. Animal and human studies indicate that berberine has cholesterol-lowering effects, according to a review. If you want to try a berberine supplement, there is a good selection of high-quality supplements available on Amazon. Evidence from clinical trials in people with type 2 diabetes suggests that berberine may lower blood sugar to a degree similar to that of some antidiabetic medications.
In fact, berberine may have the ability to change bacteria in the gut, which could help treat both obesity and diabetes. In a pilot study, 98 anovulatory people (those who don't ovulate) who were assigned a woman at birth with PCOS took berberine. Combination therapy aimed to evaluate the additive or synergistic effects of berberine on classical antidiabetic agents (study B, n %3D) 4.Compared to metformin, berberine showed an identical effect in regulating glucose metabolism, such as HbA1c, FBG, PBG, fasting insulin and insulin. If a doctor agrees that berberine is safe to use, the AANP says people should also check the product label for third-party certification, for example, from the National Science Foundation (NSF) or NSF International.
Another study states that berberine helps treat cancer by interfering with its progression and typical life cycle. Because berberine seems to have similar effects to metformin, it may also be a good treatment option for PCOS. Lipid profile of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease. For Study A, 18 subjects took 500 mg of berberine three times daily at the beginning of each main meal or 500 mg of metformin three times daily after the main meals.
A review of six randomized control trials involving 500 people found that berberine significantly reduced fatty liver in those with nonalcoholic fatty liver disease (NAFLD). .